What happens if you don’t drink a glass or two of alcohol after taking antibiotic pills? When can I drink alcohol, and how many hours or days after taking antibiotics, I can drink alcohol so as not to damage my health?
Antibiotics and alcohol
The inevitable consequence of the use of alcohol and antibiotics is the decline in the effectiveness of the treatment. After drinking, the intestinal tract will be inflamed and local immunity will decrease.
At the same time, there is an increase in antibiotic-related diseases in the intestine, which is caused by the intake of antibiotics.
Violation of drug concentration
Antibiotics begin to work when they reach a high enough therapeutic concentration in the blood. Due to the intake of the same alcoholic beverage, the amount of medicine in the body is reduced.
This drug, when trying to take antibiotics after drinking, is considered meaningless and even dangerous.
Violation of the treatment regimen, a decrease in the concentration of the drug will lead to an increase in the resistance of the pathogenic microbiota to the action of antibiotics. And this disease itself, antibiotics are against it, there is a chance to change from acute to chronic.
Because the nephrotoxic metabolite of ethanol acetaldehyde disrupts the reabsorption process of nutrients in the renal tubules, the drug concentration is reduced.
Water reabsorption is also impaired, which increases the viscosity of the blood, and the concentration of antibiotics in the blood changes in the most unpredictable way.
Characteristics of metabolism
Antibiotics are drugs that are metabolized in the liver. The liver is busy processing ethanol and has no time to neutralize all possible products of the drug's metabolism.
In addition, ethanol will affect the activity of liver enzymes, and even directly react with antibiotics or their metabolites. These properties are different in antibacterial drugs.
One of the most dangerous features of combining drugs with ethanol is the development of interactions of these compounds with disulfiram-like reactions.
Come and see if you can drink, drink beer, and take antibiotics. After that, drinking will be no danger, and then it will be absolutely impossible.
Disulfiram-like reaction
Disulfiram reaction is used to indicate alcoholism, accompanied by nausea, seizures, cough, vomiting, shortness of breath, and drop in blood pressure.
Similar effects often occur when taking alcohol-containing drugs.
The following is a list of antibiotics and when you should not drink alcohol.
The consequences of taking ethanol during antibiotic treatment are dose-dependent.
After taking pills or injecting antibiotics, you can drink alcohol-they are calculated based on the time it takes for the antibiotics to escape from the body.
List of antibiotics
Should not be consumed with alcohol:
- Nitroimidazoles-do not combine with alcohol for up to 48 hours (the drug will produce a reaction similar to disulfiram);
- Cephalosporins-The chemical structure of this group is similar in structure to the disulfiram molecule and reacts similarly to disulfiram with ethanol. You can drink alcohol the next day, kidney failure, and the interval becomes longer;
- Fluoroquinolones-Synthetic antibiotics can inhibit the nervous system and cause coma. Drink no earlier than 1. 5 days;
- Tetracycline-high risk of liver cell damage to the liver, excreted from the body for a long time. You can drink after 3 days;
- Aminoglycosides have ototoxicity and nephrotoxicity, the side effects of drugs increase, and the toxicity of drugs increases. Drinking alcohol no earlier than 0. 5 months;
- Lincosamide-The central nervous system and liver are affected, causing a disulfiram reaction. Drink alcohol 4 days after treatment;
- Macrolides-the risk of liver cirrhosis is increased, especially when taking erythromycin, it will be slowly excreted from the body. 3. Drinking is allowed after 5 days;
- Antituberculosis drugs-can cause drug-induced hepatitis, and the course of the disease is fulminant. No alcohol!
The clearance rates of antibacterial drugs in different environments of the human body are different. Therefore, if aminoglycoside antibiotics are cleared from adult blood within 2. 5 hours on average, it can be cleared from inner ear fluid for up to 350 hours this time.
In view of the ototoxicity of aminoglycoside drugs, it is easy to understand that drinking alcohol within 2 weeks after treatment can cause deafness.
interaction
Since the synthesis of enzymes that break down ethanol molecules into simple substances is blocked, disulfiram-like reactions can occur during antibiotic treatment and alcohol consumption.
As a result, the blood concentration of acetaldehyde, an intermediate product of ethanol decomposition, increases. The ethanol metabolite acetaldehyde is more toxic than ethanol itself.
And the lack of liver enzymes due to the toxic effect on the liver leads to a decrease in the synthesis of norepinephrine, which is why the symptoms of poisoning in the next morning will be more obvious and more unbearable.
Effect
The combination of small doses of alcohol and drugs may not occur at all, but when large amounts of alcohol are consumed, the side effects of drugs and alcohol will increase.
One of the most dangerous consequences of using alcohol in combination with antibiotics is a disulfiram-like reaction. The danger of this situation is that it is masked by alcoholism and is not recognized as a distress signal by others.
The disulfiram reaction is caused by an increase in the concentration of acetaldehyde in the blood, which manifests as the following symptoms:
- Palpitations;
- feel sick and vomit;
- Tide, heat;
- Dizziness;
- stomach ache;
- The pressure dropped sharply.
If the patient's blood alcohol concentration is higher than 125 mg/100 ml, and the victim does not get timely help, then even a fatal result is possible.
How to combine
Certain drugs must not be used in combination with any dose of ethanol:
- Nitroimidazole;
- A group of cephalosporins;
- Fluoroquinolones;
- Aminoglycosides.
How many days after taking antibiotics can I drink alcohol, can I interrupt the course of treatment?
It is best not to combine antibiotics and alcohol at all, and not to take ethanol during treatment. If for some reason this is not possible, and you must drink alcoholic beverages, then you can use a special alcohol calculator to calculate how long to take antibiotics after drinking alcohol.
The alcohol calculator considers a person's weight, alcohol consumption, and concentration. Therefore, for a man weighing 70 kg, 100 grams of vodka will be completely excreted from the body within 5. 8 hours, and 200 grams of beer will be excreted within 1. 44 hours.
It should be noted that all these calculations are approximate, and the actual rate of excretion from the body depends not only on the properties of these compounds, but also on the state of the kidneys, intestines, and liver.
Output
In order to completely remove the antibacterial drug from the body, it must take 1 to 3. 5-5 days. The elimination time depends on the characteristics of health, age, and metabolism.
In most cases, drinking alcohol while taking antibiotics will weaken the therapeutic effect, increase the side effects of the drug, trigger a disulfiram-like reaction, and bring serious consequences.